Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia

@inproceedings{Mizoguchi2014MicroglialIC,
  title={Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia},
  author={Yoshito Mizoguchi and Takahiro A Kato and Hideki Horikawa and Akira Monji},
  booktitle={Front. Cell. Neurosci.},
  year={2014}
}
Microglia are resident innate immune cells which release many factors including proinflammatory cytokines, nitric oxide (NO) and neurotrophic factors when they are activated in response to immunological stimuli. Recent reports show that pathophysiology of schizophrenia is related to the inflammatory responses mediated by microglia. Intracellular Ca(2+) signaling, which is mainly controlled by the endoplasmic reticulum (ER), is important for microglial functions such as release of NO and… CONTINUE READING
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