Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism.

@article{RosBernal2011MicroglialGR,
  title={Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism.},
  author={Francisco Ros-Bernal and St{\'e}phane Hunot and Mar{\'i}a Trinidad Herrero and Sebastien Parnadeau and Jean-Christophe Corvol and Lixia Lu and D. Alvarez-Fischer and Maria Angeles Carrillo-de Sauvage and Françoise Saurini and Christiane Coussieu and Kiyoka Kinugawa and Annick Prigent and G{\"u}nter U. H{\"o}glinger and Michel Hamon and François Tronche and Etienne C. Hirsch and Sheela Vyas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 16},
  pages={6632-7}
}
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pathological states. We examined the role of glucocorticoid receptors (GRs), activated by glucocorticoids released in response to stress and known to regulate inflammation, in DN… CONTINUE READING

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