Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice.

@article{Hickman2008MicroglialDA,
  title={Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice.},
  author={Suzanne E. Hickman and Elizabeth K Allison and Joseph El Khoury},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 33},
  pages={8354-60}
}
Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of beta-amyloid (Abeta) before formation of senile plaques. However, persistent Abeta accumulation despite increasing microglial numbers suggests that the ability of microglia to clear Abeta may decrease with age and progression of AD pathology. To determine the effects of aging and Abeta deposition on microglial ability to clear Abeta, we used quantitative PCR to analyze gene expression… CONTINUE READING
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