Microglial disruption in young mice with early chronic lead exposure.

  title={Microglial disruption in young mice with early chronic lead exposure.},
  author={Christina Sobin and Mayra Gisel Flores Montoya and Natali Parisi and Tanner Schaub and M Cervantes and Rodrigo X. Armijos},
  journal={Toxicology letters},
  volume={220 1},
The mechanisms by which early chronic lead (Pb) exposure alter brain development have not been identified. We examined neuroimmune system effects in C57BL/6J mice with Pb exposure, including levels that may be common among children in lower socioeconomic income environments. Pups were exposed via dams' drinking water from birth to post-natal day 28 to low, high or no Pb conditions. We compared gene expression of neuroinflammatory markers (study 1); and microglial mean cell body volume and mean… CONTINUE READING