Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.

Abstract

Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However, the mechanisms are still unclear. Here we demonstrate that neuroinflammation, cell autonomous to microglia, is capable of inducing neuronal cell cycle events (CCEs), which are toxic for terminally differentiated neurons. First, oligomeric amyloid-beta peptide (AβO… (More)
DOI: 10.1016/j.nbd.2013.10.007

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