Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

@article{Henry2019MicroglialDW,
  title={Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits},
  author={R. Henry and R. Ritzel and James P. Barrett and Sarah J. Doran and Y. Jiao and J. Leach and Gregory L Szeto and B. Stoica and A. Faden and D. Loane},
  journal={bioRxiv},
  year={2019}
}
  • R. Henry, R. Ritzel, +7 authors D. Loane
  • Published 2019
  • Biology, Medicine
  • bioRxiv
  • Chronic neuroinflammation with sustained microglial activation occurs following moderate-to-severe traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and neurological deficits. Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for their survival. In this translational study, we examined the effects of delayed depletion and subsequent repopulation of microglia on chronic… CONTINUE READING
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