Microglial control of neuronal development via somatic purinergic junctions

  title={Microglial control of neuronal development via somatic purinergic junctions},
  author={Csaba Cser{\'e}p and Anett D Schwarcz and Bal{\'a}zs P{\'o}sfai and Zs{\'o}fia I. L{\'a}szl{\'o} and Anna Kellermayer and Zsuzsanna K{\"o}rnyei and M{\'a}t{\'e} Kisfali and Mikl{\'o}s Nyerges and Zsolt Lele and Istv{\'a}n Katona and {\'A}d{\'a}m D{\'e}nes},
  journal={Cell Reports},

Figures from this paper



Microglia in CNS development: Shaping the brain for the future

Microglia contact induces synapse formation in developing somatosensory cortex

In vivo multiphoton imaging of layer 2/3 pyramidal neurons in the developing somatosensory cortex is used to demonstrate that microglial contact with dendrites directly induces filopodia formation, and provide further insights into immune system regulation of neuronal circuit development.

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

The junctions appear to provide a major site for microglia-neuron communication and may help to mediate the neuroprotective effects ofmicroglia after acute brain injury, and microglial processes at these junctions could potentially monitor and protect neuronal functions.

Layer V cortical neurons require microglial support for survival during postnatal development

A neuron-glia interaction that is indispensable for network formation during a specific period in the developing brain is highlighted, with microglia-derived IGF1 as a trophic factor that maintained neuronal survival.

Migration and differentiation of neural precursor cells can be directed by microglia

It is shown, in two different assays, that soluble factors released from mouse microglial cells direct the migration of neural CNS precursor cells and evidence is provided that microglia have the capacity to influence the differentiation of both adult and embryonic neural precursor cells toward a neuronal phenotype.

Purinergic receptors in neurogenic processes

Axon Initial Segment–Associated Microglia

It is reported that in the cortex, but not other brain regions, a subset of microglia extend a single process that specifically associates and overlaps with the axon initial segment (AIS), the site where action potentials are generated.