Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.

@article{Peyrin1999MicroglialCR,
  title={Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.},
  author={Jean Michel Peyrin and Corinne Ida Lasm{\'e}zas and St{\'e}phane Ha{\"i}k and F. Tagliavini and Mario Salmona and Alun T Williams and Daryl L Richie and J. P. Deslys and Dominique Dormont},
  journal={Neuroreport},
  year={1999},
  volume={10 4},
  pages={723-9}
}
The scrapie isoform of the prion protein (PrPres) induces neurodegeneration and gliosis in the central nervous system. These features may be reproduced in vitro on exposure of neuronal and glial cultures to PrPres and the peptide HuPr P106-126. In the present study, we investigated the role of microglial cells and astrocytes in the pathological process by studying their molecular response to PrP 106-126 exposure. PrP 106-126 elicited a specific overproduction of pro-inflammatory cytokines… CONTINUE READING
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