Microglial cells induce cytotoxic effects toward colon carcinoma cells: measurement of tumor cytotoxicity with a gamma-glutamyl transpeptidase assay.

@article{Murata1997MicroglialCI,
  title={Microglial cells induce cytotoxic effects toward colon carcinoma cells: measurement of tumor cytotoxicity with a gamma-glutamyl transpeptidase assay.},
  author={Jun Murata and Paola Ricciardi-Castagnoli and P Dessous L'Eglise Mange and François Martin and Lucienne Juillerat-Jeanneret},
  journal={International journal of cancer},
  year={1997},
  volume={70 2},
  pages={169-74}
}
Activated macrophages have been shown to exert cytostatic and cytotoxic effects toward tumor cells via nitric oxide (NO) release. In the CNS, microglial cells are considered to be the main resident population of immune effector cells. In this study, cytotoxic activity of N11, an immortalized murine microglial cell line, toward rat progressive DHD/PROb and regressive DHD/REGb colon carcinoma cells was examined in parallel with NO production. Cytotoxicity was evaluated using a novel method, the… CONTINUE READING
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