Microglial cell activation and proliferation precedes the onset of CNS autoimmunity.

  title={Microglial cell activation and proliferation precedes the onset of CNS autoimmunity.},
  author={Eugene D Ponomarev and Leah P. Shriver and Katarzyna J. Maresz and Bonnie N Dittel},
  journal={Journal of neuroscience research},
  volume={81 3},
Microglial cells are central nervous system (CNS) resident cells that are thought to become activated and contribute to the inflammation that occurs in the human autoimmune disease multiple sclerosis (MS). This has never been proven, however, because microglial cells cannot be phenotypically distinguished from peripheral macrophages that accumulate in MS inflammatory lesions. To study the kinetics and nature of microglial cell activation in the CNS, we used the animal model of MS, experimental… CONTINUE READING
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