Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype

@article{Marshall2013MicroglialAI,
  title={Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype},
  author={Simon Alex Marshall and Justin A. McClain and Matthew L. Kelso and Deann M Hopkins and Kimberly Nixon},
  journal={Neurobiology of Disease},
  year={2013},
  volume={54},
  pages={239-251}
}
Excessive alcohol intake, a defining characteristic of an alcohol use disorder (AUD), results in neurodegeneration in the hippocampus and entorhinal cortex that has been linked to a variety of cognitive deficits. Neuroinflammation is thought to be a factor in alcohol-induced neurodegeneration, and microglia activation is a key but not sole component of an inflammatory response. These experiments investigate the effects of ethanol exposure in a well-accepted model of an AUD on both microglial… CONTINUE READING

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