Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

@inproceedings{dAvila2011MicroglialAI,
  title={Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor},
  author={Joana Costa Pinto d'Avila and Tina I. Lam and Deborah Bingham and Jian Shi and Seok Joon Won and Tiina M. Kauppinen and Stephen M Massa and Jialing Liu and Raymond A Swanson},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
Traumatic brain injury (TBI) induces activation of microglia. Activated microglia can in turn increase secondary injury and impair recovery. This innate immune response requires hours to days to become fully manifest, thus providing a clinically relevant window of opportunity for therapeutic intervention. Microglial activation is regulated in part by poly… CONTINUE READING