Microglial activation and matrix protease generation during focal cerebral ischemia.

@article{Zoppo2007MicroglialAA,
  title={Microglial activation and matrix protease generation during focal cerebral ischemia.},
  author={Gregory John del Zoppo and Richard S Milner and Takuma Mabuchi and Stephanie Y Hung and Xiao-yun Wang and Greta I Berg and James A. Koziol},
  journal={Stroke},
  year={2007},
  volume={38 2 Suppl},
  pages={
          646-51
        }
}
Local environmental conditions contribute to the activation state of cells. Extracellular matrix glycoproteins participate in cell-cell boundaries within the microvascular and extravascular tissues of the central nervous system and provide a scaffold for the local environment. These conditions are altered during focal cerebral ischemia (and other central nervous system disorders) when extracellular matrix boundaries are degraded or when matrix proteins in the vascular circulation enter the… CONTINUE READING
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