Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

@article{Kakimura2002MicroglialAA,
  title={Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.},
  author={J i Kakimura and Yoshihisa Kitamura and Kazuyuki Takata and Masaaki Umeki and Sanae Suzuki and Keiichi Shibagaki and Takashi Taniguchi and Yasuyuki Nomura and Peter J. Gebicke-Haerter and Mark A. Smith and George Perry and Shun Shimohama},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 6},
  pages={601-3}
}
Alzheimer's disease (AD) is characterized by the accumulation of fibrillar amyloid-beta (Abeta) peptides to form amyloid plaques. Understanding the balance of production and clearance of Abeta peptides is the key to elucidating amyloid plaque homeostasis. Microglia in the brain, associated with senile plaques, are likely to play a major role in maintaining this balance. Here, we show that heat-shock proteins (HSPs), such as HSP90, HSP70, and HSP32, induce the production of interleukin 6 and… CONTINUE READING