Microglial Phenotype and Adaptation

@article{Eggen2013MicroglialPA,
  title={Microglial Phenotype and Adaptation},
  author={B.J.L. Eggen and Divya Raj and Uwe-karsten Hanisch and H.W.G.M. Boddeke},
  journal={Journal of Neuroimmune Pharmacology},
  year={2013},
  volume={8},
  pages={807-823}
}
Microglia are the prime innate immune cells of the central nervous system. They can transit from a (so-called) resting state under homeostatic conditions towards a pro-inflammatory activation state upon homeostatic disturbances. Under neurodegenerative conditions, microglia have been largely perceived as neurotoxic cells. It is now becoming clear that resting microglia are not inactive but that they serve house-keeping functions. Moreover, microglia activity is not limited to proinflammatory… Expand

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