Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

@article{Zhang2007MicroglialPA,
  title={Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.},
  author={Wei Zhang and Shannon Dallas and Dan Zhang and J Guo and Hao Pang and Belinda C. Wilson and David Scott Miller and Biao Chen and Wanqin Zhang and Patrick L. Mcgeer and Jau-Shyong Hong and Jing Zhang},
  journal={Glia},
  year={2007},
  volume={55 11},
  pages={1178-88}
}
alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to date largely to faster formation of alpha-synuclein aggregates in neurons. Recently, we reported that microglial activation enhances wild type (WT) alpha-synuclein-elicited… CONTINUE READING
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