Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

@article{Gu2016MicroglialPR,
  title={Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain},
  author={Nan Gu and Ukpong B Eyo and Madhuvika Murugan and Jiyun Peng and Long-Jun Wu},
  journal={Brain, Behavior, and Immunity},
  year={2016},
  volume={55},
  pages={82-92}
}
Microglial cells are critical in the pathogenesis of neuropathic pain and several microglial receptors have been proposed to mediate this process. Of these receptors, the P2Y12 receptor is a unique purinergic receptor that is exclusively expressed by microglia in the central nervous system (CNS). In this study, we set forth to investigate the role of P2Y12 receptors in microglial electrophysiological and morphological (static and dynamic) activation during spinal nerve transection (SNT)-induced… CONTINUE READING
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