Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia

  title={Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia},
  author={Mian Zhou and C. Ming Wang and Weng-Lang Yang and Ping Wang},
  journal={Brain Research},
Stroke is one of the most frequent causes of death and disability worldwide. Cerebral ischemia is the major insult of stroke and induces acute inflammation by triggering excessive production of proinflammatory cytokines, leading to the exacerbation of primary brain damage. Toll-like receptor (TLR)- and nitric oxide-mediated signaling pathways have been identified under ischemic stress. However, the interaction between these two pathways in controlling proinflammatory cytokines has not been well… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2003
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