Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

@inproceedings{Asraf2018MicroglialAI,
  title={Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies},
  author={Keren Asraf and Nofar Torika and Ron N. Apte and Sigal Fleisher-Berkovich},
  booktitle={Front. Cell. Neurosci.},
  year={2018}
}
The renin-angiotensin system (RAS) is an important peripheral system involved in homeostasis modulation, with angiotensin II (Ang II) serving as the main effector hormone. The main enzyme involved in Ang II formation is angiotensin-converting enzyme (ACE). ACE inhibitors (ACEIs) such as captopril (Cap) are predominantly used for the management of hypertension. All of the components of the RAS have also been identified in brain. Centrally located hormones such as Ang II can induce glial… CONTINUE READING

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