Microglial Aβ Receptors in Alzheimer’s Disease

  title={Microglial Aβ Receptors in Alzheimer’s Disease},
  author={Yonghao Yu and Richard D Ye},
  journal={Cellular and Molecular Neurobiology},
Amyloid β (Aβ) plays a pivotal role in the progression of Alzheimer’s disease (AD) through its neurotoxic and inflammatory effects. On one hand, Aβ binds to microglia and activates them to produce inflammatory mediators. On the other hand, Aβ is cleared by microglia through receptor-mediated phagocytosis and degradation. This review focuses on microglial membrane receptors that bind Aβ and contribute to microglial activation and/or Aβ phagocytosis and clearance. These receptors can be… CONTINUE READING
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