Microglia promote glioma migration

@article{Bettinger2001MicrogliaPG,
  title={Microglia promote glioma migration},
  author={Ina Bettinger and Solon Thanos and W. Paulus},
  journal={Acta Neuropathologica},
  year={2001},
  volume={103},
  pages={351-355}
}
Diffuse astrocytic gliomas extensively infiltrate brain tissue and contain numerous microglial cells, but it is unknown whether these two characteristic features are pathogenetically related. We therefore studied the effects of murine microglial cells on motility of GL261 mouse glioma cells using Boyden chamber assays. In the presence of microglia, glioma cell migration occurred earlier, and after 48 h it was threefold higher as compared to incubations without microglia. This effect was… CONTINUE READING

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