Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide.

@article{Gibbons2006MicrogliaIN,
  title={Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide.},
  author={Hannah M. Gibbons and Mike Dragunow},
  journal={Brain research},
  year={2006},
  volume={1084 1},
  pages={1-15}
}
Microglial cells play a major role in the pathogenesis of many neurological diseases by exacerbating neuronal and non-neuronal cell death, but the mechanisms involved are unclear. To investigate the microglial-neuronal interactions, we used the murine BV-2 microglial cell line and the human neuronal-like SK-N-SH neuroblastoma cell line in a co-culture system that enabled proximity-dependent interaction and communication, a trans-well system that allowed proximity-independent communication… CONTINUE READING
53 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

Similar Papers

Loading similar papers…