• DOI:10.1016/j.neures.2015.06.005
Corpus ID: 44555446

Microglia in the pathogenesis of autism spectrum disorders

@article{Koyama2015MicrogliaIT,
  title={Microglia in the pathogenesis of autism spectrum disorders},
  author={R. Koyama and Y. Ikegaya},
  journal={Neuroscience Research},
  year={2015},
  volume={100},
  pages={1-5}
}

R. Koyama, Y. Ikegaya

Published 2015

Psychology, Medicine

Neuroscience Research

Proper synaptic pruning is essential for the development of functional neural circuits. Impairments in synaptic pruning disrupt the excitatory versus inhibitory balance (E/I balance) of synapses, which may cause neurodevelopmental disorders such as autism spectrum disorder (ASD). Recent studies have determined molecular mechanisms by which microglia, the brain's resident immune cells, engulf inappropriate and less active synapses. Thus, microglial dysfunction may be involved in the pathogenesis… CONTINUE READING

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