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Microglia as possible therapeutic targets for autism spectrum disorders.
- BiologyProgress in molecular biology and translational science
- 2019
Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
- Biology, ChemistryMolecular Psychiatry
- 2017
It is shown that deletion of atg7 from myeloid cell-specific lysozyme M-Cre mice resulted in social behavioral defects and repetitive behaviors, characteristic features of ASDs, and the role of microglial autophagy in the regulation of the synapse and neurobehaviors is shown.
A microglia-cytokine axis to modulate synaptic connectivity and function
- Biology, PsychologyCurrent Opinion in Neurobiology
- 2017
Microbiota and Microglia Interactions in ASD
- Biology, PsychologyFrontiers in Immunology
- 2021
It is demonstrated how pre- and postnatal environmental stimuli can modulate microglial cell phenotype and function, underpinning the notion that reciprocal interactions between microglia and intestinal microbes could play a crucial role in ASD aetiology.
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.
- BiologyNature reviews. Neuroscience
- 2021
An overview of how the field of activity-dependent pruning research has evolved, led to exciting new questions and guided the identification of new, therapeutically relevant mechanisms that result in aberrant circuit development in neurodevelopmental disorders is given.
Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia
- Psychology, BiologyThe Journal of Pharmacology and Experimental Therapeutics
- 2016
The brain aberration in ASD and schizophrenia is summarized and a possible mechanism underlying social cognitive deficits in these disorders based on their distinct ages of onset is provided.
Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System
- Biology, PsychologyNeuroimmunomodulation
- 2018
This review discusses the ability of the early developing brain to respond to a focal lesion with a rapid compensatory plasticity of intact axons and the role of microglial activation and proinflammatory cytokines in brain repair and the involvement of neuroinflammatory conditions that alter neuroimmune interactions in four different pathologies.
Brain Fires in Autism Spectrum Disorders
- Biology, Psychology
- 2016
It is reported that the elevated blood levels of two inflammatory molecules, IL-6 and TNF, identify a subgroup of children with ASD, who benefit most from a promising treatment with the natural flavonoid luteolin that combats brain inflammation.
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
- Biology, PsychologyFront. Mol. Neurosci.
- 2018
Taking into account the recent identification of microglia-specific markers, and the availability of compounds that target these cells selectively in vivo, the prospect of disease intervention via the microglial route is considered.
GABA and Glutamate Imbalance in Autism and Their Reversal as Novel Hypothesis for Effective Treatment Strategy
- Biology
- 2020
It is hypothesized that an integrated treatment strategy with GABA supplements, regulation of chloride and magnesium levels, vitamin D supplements, probiotics to enhance GABAA receptor and glutamate decarboxylase (GAD) expression, and memantine to activate glutamate transporters and inhibit NMDA receptors, could collectively reduce glutamate levels, maintain functional GABA receptors and thus treat repetitive behavior, impaired social behavior, and seizure activity in individuals with autism.
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