Microglia in the pathogenesis of autism spectrum disorders

  title={Microglia in the pathogenesis of autism spectrum disorders},
  author={R. Koyama and Y. Ikegaya},
  journal={Neuroscience Research},
  • R. Koyama, Y. Ikegaya
  • Published 2015
  • Psychology, Medicine
  • Neuroscience Research
  • Proper synaptic pruning is essential for the development of functional neural circuits. Impairments in synaptic pruning disrupt the excitatory versus inhibitory balance (E/I balance) of synapses, which may cause neurodevelopmental disorders such as autism spectrum disorder (ASD). Recent studies have determined molecular mechanisms by which microglia, the brain's resident immune cells, engulf inappropriate and less active synapses. Thus, microglial dysfunction may be involved in the pathogenesis… CONTINUE READING
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