Microglia in the aging brain: relevance to neurodegeneration

@inproceedings{Luo2009MicrogliaIT,
  title={Microglia in the aging brain: relevance to neurodegeneration},
  author={Xiaoguang Luo and Jian-qing Ding and Shengdi Chen},
  booktitle={Molecular Neurodegeneration},
  year={2009}
}
Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young brain, microglia cells may be primed to react abnormally to stimuli in the aged brain and to become neurotoxic and destructive during neurodegeneration. Aging-induced immune senescence occurs in the brain as age-associated microglia senescence, which renders microglia to function abnormally and may eventually promote neurodegeneration. Microglia… CONTINUE READING

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