Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

  title={Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential},
  author={Kazuhide Inoue and Makoto Tsuda},
  journal={Nature Reviews Neuroscience},
Acute nociceptive pain is a key defence system that enables the detection of danger signals that threaten homeostasis and survival. However, chronic pain (such as the neuropathic pain that occurs after peripheral nerve injury) is not simply a consequence of the continuity of acute nociceptive signals but rather of maladaptive nervous system function. Over recent decades, studies have provided evidence for the necessity and sufficiency of microglia for the alterations in synaptic remodelling… CONTINUE READING
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Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

  • Burma, E N.
  • Nat. Med
  • 2017

Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain

  • Y Kato
  • Proc. Natl Acad. Sci. USA 114,
  • 2017

Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

  • G Corder
  • Nat. Med
  • 2017

Neuropathic pain

  • L Colloca
  • Nat. Rev. Dis. Primers
  • 2017

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