Microglia in human immunodeficiency virus-associated neurodegeneration.

  title={Microglia in human immunodeficiency virus-associated neurodegeneration.},
  author={Gwenn A. Garden},
  volume={40 2},
Infection with the human immunodeficiency virus (HIV) is associated with a syndrome of cognitive and motor abnormalities that may develop in the absence of opportunistic infections. Neurons are not productively infected by HIV. Thus, one hypothesis to explain the pathophysiology of HIV-associated dementia (HAD) suggests that signals released from other infected cell types in the CNS secondarily lead to neuronal injury. Microglia are the predominant resident CNS cell type productively infected… CONTINUE READING