Microglia in Alzheimer Brain: A Neuropathological Perspective

@inproceedings{Mrak2012MicrogliaIA,
  title={Microglia in Alzheimer Brain: A Neuropathological Perspective},
  author={Robert E. Mrak},
  booktitle={International journal of Alzheimer's disease},
  year={2012}
}
Microglia have long been noted to be present and activated in Alzheimer brain. Demonstrations that these microglia are associated with the specific lesions of Alzheimer disease-Aβ plaques and neurofibrillary tangles-and that these microglia overexpress the potent proinflammatory cytokine interleukin-1 led to the recognition of a potential pathogenic role for these cells in initiation and progression of disease. Activated, cytokine-overexpressing microglia are near-universal components of A… CONTINUE READING
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