Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

@article{Qin2002MicrogliaEB,
  title={Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.},
  author={Liya Qin and Yuxin Liu and Cynthia Cooper and Bin Liu and Belinda C Wilson and Jau-Shyong Hong},
  journal={Journal of neurochemistry},
  year={2002},
  volume={83 4},
  pages={
          973-83
        }
}
The purpose of this study was to assess and compare the toxicity of beta-amyloid (Abeta) on primary cortical and mesencephalic neurons cultured with and without microglia in order to determine the mechanism underlying microglia-mediated Abeta-induced neurotoxicity. Incubation of cortical or mesencephalic neuron-enriched and mixed neuron-glia cultures with Abeta(1-42) over the concentration range 0.1-6.0 microm caused concentration-dependent neurotoxicity. High concentrations of Abeta (6.0… CONTINUE READING

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