Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

@inproceedings{Qin2002MicrogliaE,
  title={Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species},
  author={Liya Qin and Yuxin Liu and Cynthia Lynn Cooper and Bing Liu and B. B. Cokhale Wilson and Jau-Shyong Hong},
  year={2002}
}
The purpose of this study was to assess and compare the toxicity of β-amyloid (Aβ) on primary cortical and mesencephalic neurons cultured with and without microglia in order to determine the mechanism underlying microglia-mediated Aβ-induced neurotoxicity. Incubation of cortical or mesencephalic neuron-enriched and mixed neuron–glia cultures with Aβ(1–42) over the concentration range 0.1–6.0 μm caused concentration-dependent neurotoxicity. High concentrations of Aβ (6.0 μm for cortex and 1.5–2… CONTINUE READING

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