Microglia development follows a stepwise program to regulate brain homeostasis

  title={Microglia development follows a stepwise program to regulate brain homeostasis},
  author={Orit Matcovitch-Natan and Deborah R Winter and Amir Giladi and Stephanie Vargas Aguilar and Amit Spinrad and Sandrine Sarrazin and Hila Ben-Yehuda and Eyal David and Fabiola Zelada Gonz{\'a}lez and Pierre Perrin and Hadas Keren-Shaul and Meital Gury and David Lara-Astaiso and Christoph A. Thaiss and Merav Cohen and Keren Bahar Halpern and Kuti Baruch and Aleksandra Deczkowska and Erika Lorenzo-Vivas and Shalev Itzkovitz and Eran Elinav and Michael H Sieweke and Michal Schwartz and Ido Amit},
Microglia, the resident myeloid cells of the central nervous system, play important roles in life-long brain maintenance and in pathology. Despite their importance, their regulatory dynamics during brain development have not been fully elucidated. Using genome-wide chromatin and expression profiling coupled with single-cell transcriptomic analysis throughout development, we found that microglia undergo three temporal stages of development in synchrony with the brain—early, pre-, and adult… CONTINUE READING
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