Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions.

@article{Balasubramaniam2009MicrogliaDI,
  title={Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions.},
  author={Balini Balasubramaniam and Debra A Carter and Eric J Mayer and Andrew D Dick},
  journal={Experimental eye research},
  year={2009},
  volume={89 5},
  pages={757-66}
}
Following retinal degeneration or inflammation that disrupts tissue architecture, there is limited evidence of tissue regeneration, despite evidence of cells with progenitor properties in the adult human retina at all ages. With the prospect of tissue/cell transplantation, redressing homeostasis whilst overcoming glial barrier or gliosis remains key to successful graft versus host integration and functional recovery. Activated human retinal microglia (MG) secrete cytokines, including IL-6… CONTINUE READING