Microglia-derived HIV Nef+ exosome impairment of the blood–brain barrier is treatable by nanomedicine-based delivery of Nef peptides

@article{Raymond2015MicrogliaderivedHN,
  title={Microglia-derived HIV Nef+ exosome impairment of the blood–brain barrier is treatable by nanomedicine-based delivery of Nef peptides},
  author={Andrea D Raymond and Paulo H Diaz and Semithe Chevelon and Marisela Agudelo and Adriana Yndart-Arias and Heyuan Ding and Aditi Kaushik and Rahul Dev Jayant and Roozbeh Nikkhah-Moshaie and Upal Roy and Sudheesh Pilakka-Kanthikeel and Madhavan P. N. Nair},
  journal={Journal of NeuroVirology},
  year={2015},
  volume={22},
  pages={129-139}
}
The negative factor (Nef) of human immunodeficiency virus (HIV) is an accessory protein that is thought to be integral to HIV-associated immune- and neuroimmune pathogenesis. Here, we show that nef-transfected microglia-released Nef+ exosome (exNef) disrupts the apical blood–brain barrier (BBB) and that only nef-transfected microglia release Nef in exosomes. nef–gfp-transduced neurons and astrocytes release exosomes but did not release exNef in the extracellular space. Apical administration of… CONTINUE READING
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