Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female rats.

@article{Nelson2017MicrogliaDI,
  title={Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female rats.},
  author={Lars H. Nelson and Kathryn M Lenz},
  journal={Behavioural brain research},
  year={2017},
  volume={316},
  pages={
          279-293
        }
}
Microglia, the innate immune cells of the central nervous system, regulate brain development by promoting cell genesis, pruning synapses, and removing dying, newly-born or progenitor cells. However, the role of microglia in the early life programming of behavior under normal conditions is not well characterized. We used central infusion of liposomal clodronate to selectively deplete microglia from the neonatal rat brain and subsequently assessed the impact of microglial depletion on programming… CONTINUE READING
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