Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation.


Ultrastructural three-dimensional reconstruction of human classical plaques in different stages of development shows that microglial cells are the major factor driving plaque formation by fibrillar amyloid-beta (Abeta) deposition. The amount of fibrillar Abeta released by microglial cells and the area of direct contact between amyloid and neuron determine… (More)


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