Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response.

@article{Holm2012MicrogliaAR,
  title={Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response.},
  author={Thomas Helles\oe Holm and Dina Draeby and Trevor Owens},
  journal={Glia},
  year={2012},
  volume={60 4},
  pages={630-8}
}
Within the central nervous system, astrocytes and microglia are the primary responders to endogenous ligands released upon injury and stress, as well as to infectious pathogens. Toll-like receptors (TLRs) are implicated in recognition of both types of stimulus. Whether astrocytes respond as strongly as microglia to TLR agonists remains contentious. In this study, we have rigorously purified astrocytes to determine their capacity for autonomous TLR response, in absence of microglia. We used flow… CONTINUE READING
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