Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease.

@article{Lefkowitz2008MicrogliaAM,
  title={Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease.},
  author={Doris L. Lefkowitz and Stanley S. Lefkowitz},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 5},
  pages={726-31}
}
The role of inflammation in Alzheimer's disease, Parkinson's disease, and multiple sclerosis has recently come under increased scrutiny. Associated with these inflammatory responses are tumor necrosis factor-alpha (TNF-alpha) and reactive oxygen species (ROS), both believed to be derived from brain microglia. In addition to the above, the presence of myeloperoxidase (MPO) in these diseased brains has been reported by a number of investigators. However, the possible role of MPO and enzymatically… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 74 references

Neuronal expression of myeloperoxidase is increased in Alzheimer's disease.

Journal of neurochemistry • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…