Microglia and memory: modulation by early-life infection.

  title={Microglia and memory: modulation by early-life infection.},
  author={Lauren Leshen Williamson and Paige W Sholar and Rishi S Mistry and Susan Harless Smith and Staci D. Bilbo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 43},
The proinflammatory cytokine interleukin-1β (IL-1β) is critical for normal hippocampus (HP)-dependent cognition, whereas high levels can disrupt memory and are implicated in neurodegeneration. However, the cellular source of IL-1β during learning has not been shown, and little is known about the risk factors leading to cytokine dysregulation within the HP. We have reported that neonatal bacterial infection in rats leads to marked HP-dependent memory deficits in adulthood. However, deficits are… CONTINUE READING
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