Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice.

@article{Gregersen2000MicrogliaAM,
  title={Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice.},
  author={Rikke Wulff Gregersen and Karin Lambertsen and Bente Finsen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2000},
  volume={20 1},
  pages={
          53-65
        }
}
The proinflammatory cytokine tumor necrosis factor (TNF) is known to be expressed in brain ischemia; however, its cellular and temporal appearance is not fully settled. In this study, nonradioactive in situ hybridization for murine TNF mRNA was performed on brain sections from adult C57x129 mice at 6 hours, 12 hours, 24 hours, 2 days, 5 days, or 10 days (six to eight mice per group) after induction of permanent focal cerebral ischemia. Cortical infarct volumes were estimated, and TNF mRNA… CONTINUE READING
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