Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

@article{Block2005MicrogliaAI,
  title={Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism},
  author={Michelle L. Block and Jau-Shyong Hong},
  journal={Progress in Neurobiology},
  year={2005},
  volume={76},
  pages={77-98}
}
Inflammation, a common denominator among the diverse list of neurodegenerative diseases, has recently been implicated as a critical mechanism responsible for the progressive nature of neurodegeneration. Microglia are the resident innate immune cells in the central nervous system and produce a barrage of factors (IL-1, TNFalpha, NO, PGE2, superoxide) that are toxic to neurons. Evidence supports that the unregulated activation of microglia in response to environmental toxins, endogenous proteins… CONTINUE READING
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