Microglia and inflammation in Alzheimer's disease.

  title={Microglia and inflammation in Alzheimer's disease.},
  author={Shweta Mandrekar-Colucci and Gary E. Landreth},
  journal={CNS & neurological disorders drug targets},
  volume={9 2},
One hundred and fifty years have elapsed since the original discovery of the microglial cell by Virchow. While this cell type has been well studied, the role of microglia in the pathology of many central nervous system diseases still remains enigmatic. It is widely accepted that microglial-mediated inflammation contributes to the progression of Alzheimer's disease (AD); however, the precise mechanisms through which these cells contribute to AD-related inflammation remains to be elucidated. In… CONTINUE READING
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