Microglia activation in retinal degeneration.

  title={Microglia activation in retinal degeneration.},
  author={Thomas Langmann},
  journal={Journal of leukocyte biology},
  volume={81 6},
Microglia cells are phagocytic sentinels in the CNS and in the retina required for neuronal homeostasis and innate immune defense. Accumulating experimental evidence suggests that chronic microglia activation is associated with various neurodegenerative diseases including retinal dystrophies. Endogenous triggers alert microglia cells rapidly in the degenerating retina, leading to local proliferation, migration, enhanced phagocytosis, and secretion of cytokines, chemokines, and neurotoxins. This… CONTINUE READING
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