Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

@article{Berckel2008MicrogliaAI,
  title={Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.},
  author={Bart N. M. van Berckel and Matthijs G. Bossong and Ronald Boellaard and Reina W. Kloet and Alie Schuitemaker and Esther Caspers and Gert Luurtsema and Albert D. Windhorst and Wiepke Cahn and Adriaan A. Lammertsma and Ren{\'e} S. Kahn},
  journal={Biological psychiatry},
  year={2008},
  volume={64 9},
  pages={820-2}
}
BACKGROUND Schizophrenia is a brain disease involving progressive loss of gray matter of unknown cause. Most likely, this loss reflects neuronal damage, which should, in turn, be accompanied by microglia activation. Microglia activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography (PET). The purpose of this study was to investigate whether microglia activation occurs in patients with recent-onset schizophrenia. METHODS Ten patients with recent-onset… CONTINUE READING

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