Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge.

@article{GonzlezPea2016MicrogliaTC,
  title={Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge.},
  author={Dianelys Gonz{\'a}lez-Pe{\~n}a and Scott E. Nixon and Jason C. O'Connor and Bruce R. Southey and Marcus A. Lawson and Robert H. McCusker and Tania Borras and Debbie Machuca and Alvaro G. Hernandez and Robert Dantzer and Keith W. Kelley and Sandra L. Rodriguez-Zas},
  journal={PloS one},
  year={2016},
  volume={11 3},
  pages={
          e0150858
        }
}
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of inflammation-associated depressive behavior was undertaken. The transcriptome of microglia from mice at day 7 after Bacille Calmette Guérin (BCG) challenge was compared to that from unchallenged Control mice and to the transcriptome from peripheral macrophages from the same mice. Among the 562 and 3… CONTINUE READING
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