Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.

@article{Harada2002MicrogliaMllerGC,
  title={Microglia-M{\"u}ller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.},
  author={Takayuki Harada and Chikako Harada and Shinichi Kohsaka and Etsuko Wada and Kazuhiko Yoshida and Shigeaki Ohno and Hiroshi Mamada and Kohichi Tanaka and Luis F. Parada and Keiji Wada},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 21},
  pages={9228-36}
}
Activation of microglia commonly occurs in response to a wide variety of pathological stimuli including trauma, axotomy, ischemia, and degeneration in the CNS. In the retina, prolonged or high-intensity exposure to visible light leads to photoreceptor cell apoptosis. In such a light-reared retina, we found that activated microglia invade the degenerating photoreceptor layer and alter expression of neurotrophic factors such as nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), and… CONTINUE READING