Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

@article{Tay2018MicrogliaGR,
  title={Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan},
  author={Tuan Leng Tay and Catherine B{\'e}chade and Ivana D’Andrea and Marie-Kim St-Pierre and Mathilde S. Henry and Anne Roumier and M E Tremblay},
  journal={Frontiers in Molecular Neuroscience},
  year={2018},
  volume={10}
}
Microglia are the predominant immune response cells and professional phagocytes of the central nervous system (CNS) that have been shown to be important for brain development and homeostasis. These cells present a broad spectrum of phenotypes across stages of the lifespan and especially in CNS diseases. Their prevalence in all neurological pathologies makes it pertinent to reexamine their distinct roles during steady-state and disease conditions. A major question in the field is determining… 

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References

SHOWING 1-10 OF 424 REFERENCES

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

This review highlights recent studies on microglial origin (from the embryonic yolk sac) and the factors regulating their differentiation and homeostasis upon brain invasion and the implications of the depletion or dysfunction of microglia for the authors' understanding of disease pathogenesis.

An updated assessment of microglia depletion: current concepts and future directions

The highly plastic and diverse phenotypes of microglia are highlighted and lessons learned from microglian depletion approaches are outlined, thus holding promise for designing strategies to resolve neuroinflammation and promote recovery.

Microglia under psychosocial stressors along the aging trajectory: Consequences on neuronal circuits, behavior, and brain diseases

  • L. TianC. Hui M. Tremblay
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2017

Microglial brain region-dependent diversity and selective regional sensitivities to ageing

It is found that microglia have distinct region-dependent transcriptional identities and age in a regionally variable manner, and in the young adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of heterogeneity and suggested that cerebellar and hippocampalmicroglia exist in a more immune-vigilant state.

Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood

Microglia depletion experiments revealed an essential role of postnatal microglia for the proper development and homeostasis of oligodendrocytes and their progenitors and provide new cellular and molecular insights into the myelin-supporting function ofmicroglia in the normal CNS.

Dark microglia: A new phenotype predominantly associated with pathological states

Findings suggest that dark microglia, a new phenotype that is rarely present under steady state conditions, but becomes abundant during chronic stress, aging, fractalkine signaling deficiency, and Alzheimer's disease pathology, could play a significant role in the pathological remodeling of neuronal circuits, especially at synapses.

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

The vulnerability of microglia to dysfunction is described and it is proposed that myelomonocytic cells might be used in the treatment of neurological and psychiatric disorders that are characterized by primary or secondary 'microgliopathy'.

Microglia development follows a stepwise program to regulate brain homeostasis

It is found that microglia from germ-free mice exhibited dysregulation of dozens of genes associated with the adult phase and immune response, including MAFB, which led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways.

A novel microglial subset plays a key role in myelinogenesis in developing brain

It is shown that in contrast to healthy adult and inflammation‐activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype that deliver signals necessary for myelination and neurogenesis.
...