Microglia: proliferation and activation driven by the P2X7 receptor.

  title={Microglia: proliferation and activation driven by the P2X7 receptor.},
  author={Mastura Monif and Geoffrey Burnstock and David A Williams},
  journal={The international journal of biochemistry & cell biology},
  volume={42 11},
Microglial activation is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD), Parkinsons' disease, prion disease, multiple sclerosis, and ischemic and traumatic brain injury. The molecular mechanism of microglial activation is largely unknown. The expression of the purinergic, P2X7 receptor (P2X7R), is known to be enhanced in many brain pathologies where presence of activated microglia is a concurrent feature. This review focuses on the links between… CONTINUE READING


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