Microglia: neuroprotective and neurotrophic cells in the central nervous system.

  title={Microglia: neuroprotective and neurotrophic cells in the central nervous system.},
  author={Kazuyuki Nakajima and Shinichi Kohsaka},
  journal={Current drug targets. Cardiovascular & haematological disorders},
  volume={4 1},
Microglia are currently accepted as sensor cells in the central nervous system that respond to injury and brain disease. The main function of microglia is believed to be brain defense, as they are known to scavenge invading microorganisms and dead cells, and also to act as immune or immunoeffector cells. However, microglia are also thought to contribute to the onset of or to exacerbate neuronal degeneration and/or inflammation in many brain diseases by producing deleterious factors including… CONTINUE READING

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