Microglia: actively surveying and shaping neuronal circuit structure and function.

@article{Wake2013MicrogliaAS,
  title={Microglia: actively surveying and shaping neuronal circuit structure and function.},
  author={Hiroaki Wake and Andrew J Moorhouse and Akiko Miyamoto and Junichi Nabekura},
  journal={Trends in neurosciences},
  year={2013},
  volume={36 4},
  pages={209-17}
}
The traditional role of microglia has been in brain infection and disease, phagocytosing debris and secreting factors to modify disease progression. Recent evidence extends their role to healthy brain homeostasis, including the regulation of cell death, synapse elimination, neurogenesis, and neuronal surveillance. These actions contribute to the maturation and plasticity of neural circuits that ultimately shape behavior. Here we review microglial contributions to the development, plasticity… CONTINUE READING
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