Microglia/macrophage polarization dynamics in white matter after traumatic brain injury.

  title={Microglia/macrophage polarization dynamics in white matter after traumatic brain injury.},
  author={Guohua Wang and Jia Zhang and Xiaoming Hu and Lili Zhang and Leilei Mao and Xiaoyan Jiang and Anthony Kian-Fong Liou and Rehana K Leak and Yanqin Gao and Jun Chen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={33 12},
Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in traumatic brain injury (TBI) are, however, poorly characterized. In the present study, TBI was induced in mice by a controlled cortical impact (CCI) and animals were killed at 1 to 14 days post injury. Real-time polymerase chain reaction (RT-PCR) and immunofluorescence staining for M1 and M2 markers were performed to… CONTINUE READING
Highly Cited
This paper has 187 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 120 extracted citations

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.

Proceedings of the National Academy of Sciences of the United States of America • 2015
View 6 Excerpts
Highly Influenced

187 Citations

Citations per Year
Semantic Scholar estimates that this publication has 187 citations based on the available data.

See our FAQ for additional information.