Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon

@article{Cole2003MicroformHI,
  title={Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon},
  author={Francesca Cole and Robert S Krauss},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={411-415}
}
Holoprosencephaly (HPE), the most common developmental defect of the forebrain and midface, is caused by a failure to delineate the midline in these structures. Despite the identification of several HPE genes, its genetic basis is largely unknown. Furthermore, the phenotype of affected individuals is highly variable, even within pedigrees. Facial defects in HPE range from cyclopia and proboscis in severe cases to solitary median maxillary central incisor in individuals with microforms of HPE… CONTINUE READING